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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > O6-BenzylguanineCAS：19916-73-5
Molecular Formula：C12H11N5O
Molecular Weight：241.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 19916-73-5 |
| Name | O6-Benzylguanine |
| Molecular Formula | C12H11N5O |
| Molecular Weight | 241.25 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 449-870-7 |
| MDL | MFCD00269931 |
| SMILES | C1=CC=C(C=C1)COC2=NC(=NC3=C2NC=N3)N |
| InChIKey | KRWMERLEINMZFT-UHFFFAOYSA-N |
| InChI | InChI=1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5，7H，6H2，(H3，13，14，15，16，17) |
| PubChem CID | 4578 |
| Target Point | MGMT/AGT |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | O6-benzylguanine, a guanine analogue, is an inhibitor of the DNA repair enzyme O6 alkyl guanine DNA alkyl transferase (MGMT/AGT). O6-Benzylguanine acts as an AGT substrate, transferring its benzyl group to the AGT cysteine residue, which irreversibly inactivates AGT and prevents DNA repair. O6-Benzylguanine can induce apoptosis of tumor cells and has antitumor activity. |
| Unit | Bottle |
| Specification | 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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