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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Ubiquitin > VLX-1570CAS：1431280-51-1
Molecular Formula：C23H17F2N3O6
Molecular Weight：469.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1431280-51-1 |
| Name | VLX-1570 |
| Molecular Formula | C23H17F2N3O6 |
| Molecular Weight | 469.39 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C=CC(=O)N1CCC(=CC2=CC(=C(C=C2)F)[N+](=O)[O-])C(=O)C(=CC3=CC(=C(C=C3)F)[N+](=O)[O-])C1 |
| InChIKey | SCKXBVLYWLLALY-CQRYCMKKSA-N |
| InChI | InChI=1S/C23H17F2N3O6/c1-2-22(29)26-8-7-16(9-14-3-5-18(24)20(11-14)27(31)32)23(30)17(13-26)10-15-4-6-19(25)21(12-15)28(33)34/h2-6，9-12H，1，7-8，13H2/b16-9-，17-10- |
| PubChem CID | 118989091 |
| Target Point | Deubiquitinases (DUBs) |
| Passage | Ubiquitin |
| Background | VLX1570 is a competitive inhibitor of proteasome deubiquitinase (DUBs). |
| Biological Activity | VLX1570 is a competitive inhibitor of proteasome deubiquitinases (DUBs) with an IC50 of approximate 10 μM.[1-3] |
| IC50 | IC50: appr 10?μM (Deubiquitinase)[2] |
| Data Literature Source | [1]. Wang X， et al. Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15. Chem Biol Drug Des. 2015 Nov;86(5):1036-48. [2]. Wang X， et al. The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep. 2016 Jun 6;6:26979. [3]. Paulus A， et al. Coinhibition of the deubiquitinating enzymes， USP14 and UCHL5， with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells. Blood Cancer J. 2016 Nov 4;6(11):e492. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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