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XL388

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Cat.No：IX0350 Solarbio

CAS：1251156-08-7

Molecular Formula：C₂₃H₂₂FN₃O₄S

Molecular Weight：455.5

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1251156-08-7
Name	XL388
Molecular Formula	C₂₃H₂₂FN₃O₄S
Molecular Weight	455.5
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	CC1=C(C=CC(=C1F)S(=O)(=O)C)C(=O)N2CCOC3=C(C2)C=C(C=C3)C4=CN=C(C=C4)N
InChIKey	LNFBAYSBVQBKFR-UHFFFAOYSA-N
InChI	InChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2，29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8，11-12H，9-10，13H2，1-2H3，(H2，25，26)
PubChem CID	59604787
Target Point	mTOR
Passage	PI3K/Akt/mTOR
Background	XL388 is a potent ATP-competitive mTOR inhibitor that inhibits both mTORC1 and mTORC2.
Biological Activity	XL388 is a highly potent and ATP-competitive mTOR inhibitor with an IC50 of 9.9 nM. XL388 simultaneously inhibits both mTORC1 and mTORC2.[1-2]
Data Literature Source	[1]. Takeuchi CS， et al. Discovery of a novel class of highly potent， selective， ATP-competitive， and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR). J Med Chem. 2013 Mar 28;56(6):2218-34. [2]. Zhu YR， et al. The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models. Oncotarget. 2016 Aug 2;7(31):49527-49538.
Unit	Bottle
Specification	1mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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