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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > NMS-P715CAS：1202055-32-0
Molecular Formula：C35H39F3N8O3
Molecular Weight：676.73
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1202055-32-0 |
| Name | NMS-P715 |
| Molecular Formula | C35H39F3N8O3 |
| Molecular Weight | 676.73 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CCC1=C(C(=CC=C1)CC)NC(=O)C2=NN(C3=C2CCC4=CN=C(N=C43)NC5=C(C=C(C=C5)C(=O)NC6CCN(CC6)C)OC(F)(F)F)C |
| InChIKey | JFOAJUGFHDCBJJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C35H39F3N8O3/c1-5-20-8-7-9-21(6-2)28(20)42-33(48)30-25-12-10-23-19-39-34(43-29(23)31(25)46(4)44-30)41-26-13-11-22(18-27(26)49-35(36，37)38)32(47)40-24-14-16-45(3)17-15-24/h7-9，11，13，18-19，24H，5-6，10，12，14-17H2，1-4H3，(H，40，47)(H，42，48)(H，39，41，43) |
| PubChem CID | 44556162 |
| Target Point | Mps1 |
| Passage | Cell Cycle; Cytoskeleton |
| Background | NMS-P715 is a selective, ATP-competitive inhibitor of MPS1. |
| Biological Activity | NMS-P715 is a selective， ATP-competitive inhibitor of MPS1， with an IC50 of 182 nM.[1-2] |
| Data Literature Source | [1]. Colombo R， et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715， an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64. [2]. Slee RB， et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther. 2014 Feb;13(2):307-315. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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