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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > GSK-1838705ACAS：1116235-97-2
Molecular Formula：C27H29FN8O3
Molecular Weight：532.57
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1116235-97-2 |
| Name | GSK-1838705A |
| Molecular Formula | C27H29FN8O3 |
| Molecular Weight | 532.57 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD19443644 |
| SMILES | CNC(=O)C1=C(C=CC=C1F)NC2=NC(=NC3=C2C=CN3)NC4=C(C=C5CCN(C5=C4)C(=O)CN(C)C)OC |
| InChIKey | HZTYDQRUAWIZRE-UHFFFAOYSA-N |
| InChI | InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8，10，12-13H，9，11，14H2，1-4H3，(H，29，38)(H3，30，31，32，33，34) |
| PubChem CID | 25182616 |
| Target Point | IGF-IR;insulin receptor; Anaplastic lymphoma kinase (ALK) |
| Passage | Protein Tyrosine Kinase/RTK;Endocrinology & Hormones |
| Background | GSK-1838705A is a highly potent, reversible IGF-IR and insulin receptor inhibitor that also inhibits ALK. |
| Biological Activity | GSK1838705A is a potent and reversible IGF-IR and the insulin receptor inhibitor with IC50s of 2.0 and 1.6 nM， respectively. It also inhibits ALK with an IC50 of 0.5 nM.[1] |
| IC50 | IC50: 2.0 nM (IGF-IR)， 1.6 nM (insulin receptor)， 0.5 nM (ALK)[1] |
| Data Literature Source | [1]. Sabbatini P， et al. GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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