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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > SD-208CAS：627536-09-8
Molecular Formula：C17H10ClFN6
Molecular Weight：352.75
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 627536-09-8 |
| Name | SD-208 |
| Molecular Formula | C17H10ClFN6 |
| Molecular Weight | 352.75 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11519969 |
| SMILES | C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F |
| InChIKey | BERLXWPRSBJFHO-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H，(H，20，22，23，24，25) |
| PubChem CID | 10316032 |
| Target Point | TGF-β Receptor |
| Passage | TGF-beta/Smad |
| Background | SD-208 is a selective inhibitor of TGF-βRI (ALK5). |
| Biological Activity | SD-208 is a selective?TGF-βRI (ALK5)?inhibitor with?IC50?of 48 nM， and > 100-fold selectivity over TGF-βRII.[1-3] |
| IC50 | IC50: 48 nM (TGF-βRI)[1-3] |
| Data Literature Source | [1]. Uhl M， et al. SD-208， a novel transforming growth factor beta receptor I kinase inhibitor， inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004 Nov 1;64(21):7954-61. [2]. Ge R， et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4315-30. [3]. Sun Y， et al. Inhibition of intimal hyperplasia in murine aortic allografts by the oral administration of the transforming growth factor-beta receptor I kinase inhibitor SD-208. J Heart Lung Transplant. 2014 Jun;33(6):654-61. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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