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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > ISCK03CAS：945526-43-2
Molecular Formula：C19H21N3O2S
Molecular Weight：355.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to light brown Solid
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| CAS | 945526-43-2 |
| Name | ISCK03 |
| Molecular Formula | C19H21N3O2S |
| Molecular Weight | 355.46 |
| Solubility | Soluble in DMSO ≥4mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Off-white to light brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12031591 |
| SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3 |
| InChIKey | XQABBHBFHWHMKF-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H21N3O2S/c1-19(2，3)15-4-10-18(11-5-15)25(23，24)21-16-6-8-17(9-7-16)22-13-12-20-14-22/h4-14，21H，1-3H3 |
| PubChem CID | 3792751 |
| Target Point | stem-cell factor (SCF);c-kit |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | ISCK03 is a specific stem-cell factor (SCF)/c-kit inhibitor. |
| Biological Activity | ISCK03 is a SCF/c-Kit and CD117-specific inhibitor. ISCK03 significantly inhibits c-Kit phosphorylation at 10 μM.[1-3] |
| Data Literature Source | [1]. Wintzell M， et al. Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate. Cancer Biol Ther. 2012 Dec;13(14):1454-62. [2]. Na YJ， et al. [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. Biochem Pharmacol. 2007 Sep 1;74(5):780-6. [3]. Hirano T， et al. Long noncoding RNA， CCDC26， controls myeloid leukemia cell growth through regulation of KIT expression. Mol Cancer. 2015 Apr 19;14:90. doi: 10.1186/s12943-015-0364-7. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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