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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > OSI-027CAS：936890-98-1
Molecular Formula：C21H22N6O3
Molecular Weight：406.44
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 936890-98-1 |
| Name | OSI-027 |
| Molecular Formula | C21H22N6O3 |
| Molecular Weight | 406.44 |
| Solubility | Soluble in DMSO ≥10mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD20275101 |
| SMILES | COC1=CC=CC2=C1NC(=C2)C3=C4C(=NC=NN4C(=N3)C5CCC(CC5)C(=O)O)N |
| InChIKey | JROFGZPOBKIAEW-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H22N6O3/c1-30-15-4-2-3-13-9-14(25-16(13)15)17-18-19(22)23-10-24-27(18)20(26-17)11-5-7-12(8-6-11)21(28)29/h2-4，9-12，25H，5-8H2，1H3，(H，28，29)(H2，22，23，24) |
| PubChem CID | 135398516 |
| Target Point | mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | OSI-027 is an ATP competitive inhibitor of mTOR kinase activity. |
| Biological Activity | OSI-027 (ASP7486) is a potent， selective， orally active and ATP-competitive mTOR kinase activity inhibitor with an IC50 of 4 nM. OSI-027 targets both mTORC1 and mTORC2 with IC50s of 22 nM and 65 nM， respectively.[1-4] |
| Data Literature Source | [1]. Falcon BL， et al. Reduced VEGF production， angiogenesis， and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res. 2011 Mar 1;71(5):1573-83. [2]. Mateo J， et al. A first in man， dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies. Br J Cancer. 2016;114(8):889-896. [3]. Zhang Y， et al. PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer. EBioMedicine. 2015 Nov 19;2(12):1944-56. [4]. Zhi X， et al. OSI-027 modulates acute graft-versus-host disease after liver transplantation in a rat model. Liver Transpl. 2017 Sep;23(9):1186-1198. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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