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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Ubiquitin > LDN-57444CAS：668467-91-2
Molecular Formula：C17H11Cl3N2O3
Molecular Weight：397.64
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 668467-91-2 |
| Name | LDN-57444 |
| Molecular Formula | C17H11Cl3N2O3 |
| Molecular Weight | 397.64 |
| Solubility | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09037562 |
| SMILES | CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl |
| InChIKey | OPQRFPHLZZPCCH-PGMHBOJBSA-N |
| InChI | InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H，8H2，1H3/b21-16- |
| PubChem CID | 16760696 |
| Target Point | UCH-L1 |
| Passage | Ubiquitin |
| Background | LDN-57444 is a reversible， competitive inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1). |
| Biological Activity | LDN-57444 is a reversible， competitive and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1)， with an IC50 of 0.88 μM and a Ki of 0.40 μM; LDN-57444 also suppresses UCH-L3 activity， with an IC50 of 25 μM.[1-3] |
| IC50 | IC50: 0.88 μM (UCH-L1)， 25 μM (UCH-L3)[1]Ki: 0.40 μM (UCH-L1)[1] |
| Data Literature Source | [1]. Liu Y， et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol. 2003 Sep;10(9):837-46. [2]. Gong B， et al. Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell. 2006 Aug 25;126(4):775-88. [3]. Tan YY， et al. Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol Cell Biochem. 2008 Nov;318(1-2):109-15. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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