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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > KN-62CAS：127191-97-3
Molecular Formula：C38H35N5O6S2
Molecular Weight：721.84
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 127191-97-3 |
| Name | KN-62 |
| Molecular Formula | C38H35N5O6S2 |
| Molecular Weight | 721.84 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00083180 |
| SMILES | CN(C(CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7 |
| InChIKey | RJVLFQBBRSMWHX-DHUJRADRSA-N |
| InChI | InChI=1S/C38H35N5O6S2/c1-41(50(45，46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47，48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20，26-27，35H，21-25H2，1H3/t35-/m0/s1 |
| PubChem CID | 5312126 |
| Target Point | CaMK;P2X7 |
| Passage | Neuronal Signaling;Membrane Transporter&Ion Channel |
| Background | KN-62 is a potent， selective calmodulin-dependent protein kinase II (CaMK-II) inhibitor and a non-competitive P2X7 receptor antagonist. |
| Biological Activity | KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a Ki of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X7 receptors in HEK293 cells， with an IC50 value of approximately 15 nM.[1-5] |
| Data Literature Source | [1]. Gargett CE， et al. The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br J Pharmacol. 1997 Apr;120(8):1483-90. [2]. H Hidaka， et al. Pharmacology of protein kinase inhibitors. Annu Rev Pharmacol Toxicol. 1992;32:377-97. [3]. Miso Park， et al. Involvement of the P2X7 receptor in the migration and metastasis of tamoxifen-resistant breast cancer: effects on small extracellular vesicles production. Sci Rep. 2019 Aug 12;9(1):11587. [4]. Ravi RG， et al. Potent P2X7 Receptor Antagonists: Tyrosyl Derivatives Synthesized Using a Sequential Parallel Synthetic Approach. Drug Dev Res. 2001 Oct;54(2):75-87. [5]. Manosso LM， et al. Antidepressant-like effect of zinc is dependent on signaling pathways implicated in BDNF modulation. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jun 3;59:59-67. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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