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AR 231453

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Cat.No：IA7110 Solarbio

CAS：733750-99-7

Molecular Formula：C₂₁H₂₄FN₇O₅S

Molecular Weight：505.52

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	733750-99-7
Name	AR 231453
Molecular Formula	C₂₁H₂₄FN₇O₅S
Molecular Weight	505.52
Solubility	Soluble in DMSO ≥3mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD14706714
SMILES	CC(C)C1=NOC(=N1)C2CCN(CC2)C3=NC=NC(=C3[N+](=O)[O-])NC4=C(C=C(C=C4)S(=O)(=O)C)F
InChIKey	DGBKNTVAKIFYNU-UHFFFAOYSA-N
InChI	InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3，32)33/h4-5，10-13H，6-9H2，1-3H3，(H，23，24，25)
PubChem CID	24939268
Target Point	GPR119
Passage	GPCR & G Protein
Background	AR 231453 is an effective， selective agonist for GPR119.
Biological Activity	AR 231453 is a potent， specific and orally available GPR119 agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s[1][2].
Data Literature Source	[1]. Chu ZL，et al. A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release. Endocrinology. 2007 Jun;148(6):2601-9. [Content Brief] [2]. J Gao，et al. Stimulating β-cell replication and improving islet graft function by AR231453，A GPR119 agonist. Transplant Proc. 2011 Nov;43(9):3217-20.
Unit	Bottle
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.

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