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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > AcelarinCAS：840506-29-8
Molecular Formula：C25H27F2N4O8P
Molecular Weight：580.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 840506-29-8 |
| Name | Acelarin |
| Molecular Formula | C25H27F2N4O8P |
| Molecular Weight | 580.47 |
| Solubility | Soluble in DMSO ≥3mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD27987942 |
| SMILES | CC(C(=O)OCC1=CC=CC=C1)NP(=O)(OCC2C(C(C(O2)N3C=CC(=NC3=O)N)(F)F)O)OC4=CC=CC=C4 |
| InChIKey | NHTKGYOMICWFQZ-KKQYNPQSSA-N |
| InChI | InChI=1S/C25H27F2N4O8P/c1-16(22(33)36-14-17-8-4-2-5-9-17)30-40(35，39-18-10-6-3-7-11-18)37-15-19-21(32)25(26，27)23(38-19)31-13-12-20(28)29-24(31)34/h2-13，16，19，21，23，32H，14-15H2，1H3，(H，30，35)(H2，28，29，34)/t16-，19+，21+，23+，40?/m0/s1 |
| PubChem CID | 11169170 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | It is an inhibitor of DNA synthesis. |
| Biological Activity | Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue， gemcitabine.[1] |
| IC50 | EC50：0.2 nM (DNA synthesis inhibitor)[1] |
| Data Literature Source | [1]. Slusarczyk M， et al. Application of ProTide technology to gemcitabine: a successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development. J Med Chem. 2014 Feb 27;57(4):1531-42. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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