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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > (Rac)-PF-184 HydrateCAS：1187460-81-6(free base)
Molecular Formula：C32H34ClFN6O5
Molecular Weight：659.64
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1187460-81-6(free base) |
| Name | (Rac)-PF-184 Hydrate |
| Molecular Formula | C32H34ClFN6O5 |
| Molecular Weight | 659.64 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C[C@@]1(CN(C[C@@]1(C)CO)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl)CO |
| InChIKey | JUOWWGNRWRLBSV-MEKGRNQZSA-N |
| InChI | InChI=1S/C32H32ClFN6O4/c1-31(16-41)14-39(15-32(31，2)17-42)26-12-24(25(33)13-36-26)30(44)37-20-7-3-18-4-10-22-27(29(35)43)38-40(28(22)23(18)11-20)21-8-5-19(34)6-9-21/h3，5-9，11-13，41-42H，4，10，14-17H2，1-2H3，(H2，35，43)(H，37，44)/t31-，32+ |
| PubChem CID | 57519531 |
| Target Point | IKK-2 |
| Passage | NF-κB |
| Background | (Rac)-PF-184 hydrate is an effective inhibitory factor of inhibitory factor-κB kinase 2 (IKK-2). |
| Biological Activity | (Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects[1]. |
| Data Literature Source | [1]. Sommers CD，et al. Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. J Pharmacol Exp Ther. 2009 Aug;330(2):377-88. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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