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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > PF-04991532CAS：1215197-37-7
Molecular Formula：C18H19F3N4O3
Molecular Weight：396.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1215197-37-7 |
| Name | PF-04991532 |
| Molecular Formula | C18H19F3N4O3 |
| Molecular Weight | 396.36 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1CCC(C1)C[C@@H](C(=O)NC2=NC=C(C=C2)C(=O)O)N3C=C(N=C3)C(F)(F)F |
| InChIKey | GKMLFBRLRVQVJO-ZDUSSCGKSA-N |
| InChI | InChI=1S/C18H19F3N4O3/c19-18(20，21)14-9-25(10-23-14)13(7-11-3-1-2-4-11)16(26)24-15-6-5-12(8-22-15)17(27)28/h5-6，8-11，13H，1-4，7H2，(H，27，28)(H，22，24，26)/t13-/m0/s1 |
| PubChem CID | 46181428 |
| Target Point | Glucokinase |
| Passage | Metabolic Enzyme&Protease |
| Background | PF-04991532 is an effective liver selective glucokinase activator. |
| Biological Activity | PF-04991532 is a potent， hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat， respectively.[1] |
| IC50 | EC50: 80 nM (glucokinase in human)， 100 nM (glucokinase in rat)[1] |
| Data Literature Source | [1]. Erion DM， et al. The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats. PLoS One. 2014 May 23;9(5):e97139. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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