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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > PF-04457845CAS：1020315-31-4
Molecular Formula：C23H20F3N5O2
Molecular Weight：455.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1020315-31-4 |
| Name | PF-04457845 |
| Molecular Formula | C23H20F3N5O2 |
| Molecular Weight | 455.43 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18782721 |
| SMILES | C1CN(CCC1=CC2=CC(=CC=C2)OC3=NC=C(C=C3)C(F)(F)F)C(=O)NC4=NN=CC=C4 |
| InChIKey | BATCTBJIJJEPHM-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H20F3N5O2/c24-23(25，26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7，10，13-15H，8-9，11-12H2，(H，29，30，32) |
| PubChem CID | 24771824 |
| Target Point | FAAH |
| Passage | Metabolic Enzyme&Protease |
| Background | PF-04457845 is a highly selective FAAH inhibitor that acts on both hFAAH and rFAAH. |
| Biological Activity | PF-04457845 is a highly efficacious and selective FAAH inhibitor with IC50 values is 7.2±0.63 nM and 7.4±0.62 nM for hFAAH and rFAAH， respectively.[1-2] |
| IC50 | IC50: 7.2±0.63nM(hFAAH);7.4±0.62nM(rFAAH)[1] |
| Data Literature Source | [1]. Johnson DS，et al. Discovery of PF-04457845: A Highly Potent，Orally Bioavailable，and Selective Urea FAAH Inhibitor. ACS Med Chem Lett. 2011 Feb 10;2(2):91-96. [Content Brief] [2]. Ahn K，et al. Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. J Pharmacol Exp Ther. 2011 Jul;338(1):114-24. [Content Brief] |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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