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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > HS38CAS：1030203-81-6
Molecular Formula：C14H12ClN5O2S
Molecular Weight：349.8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1030203-81-6 |
| Name | HS38 |
| Molecular Formula | C14H12ClN5O2S |
| Molecular Weight | 349.8 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC(C(=O)N)SC1=NC2=C(C=NN2C3=CC(=CC=C3)Cl)C(=O)N1 |
| InChIKey | NASYEGAVCTZSDO-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H12ClN5O2S/c1-7(11(16)21)23-14-18-12-10(13(22)19-14)6-17-20(12)9-4-2-3-8(15)5-9/h2-7H，1H3，(H2，16，21)(H，18，19，22) |
| PubChem CID | 135398509 |
| Target Point | DAPK1;ZIPK (DAPK3);PIM3 |
| Passage | Apoptosis;JAK/STAT Signaling |
| Background | HS38 is a highly potent, selective, ATP-competitive inhibitor of DAPK1 and ZIPK (DAPK3). HS38 is also an inhibitor of PIM3. |
| Biological Activity | HS38 is a potent， selective， and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK， also called DAPK3)， with Kds of 300 nM and 280 nM， respectively. HS38 is also a PIM3 inhibitor with an IC50 of 200 nM. HS38 can be used for the research of smooth muscle related disorders[1]. |
| IC50 | 300nM(DAPK1);79nM(DAPK2);280nM(ZIPK);IC50: 200nM(DAPK1);200nM(PIM3)[1] |
| Data Literature Source | [1]. David A Carlson，et al. Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor. ACS Chem Biol. 2013 Dec 20; 8(12): 2715–2723. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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