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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > Liothyronine SodiumCAS：1955/6/1
Molecular Formula：C15H11I3NNaO4
Molecular Weight：672.96
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 1955/6/1 |
| Name | Liothyronine Sodium |
| Molecular Formula | C15H11I3NNaO4 |
| Molecular Weight | 672.96 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00002594 |
| SMILES | C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)[O-])N)I)I)O.[Na+] |
| InChIKey | SBXXSUDPJJJJLC-YDALLXLXSA-M |
| InChI | InChI=1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4，6，12，20H，5，19H2，(H，21，22);/q;+1/p-1/t12-;/m0./s1 |
| PubChem CID | 23666110 |
| Target Point | Thyroid Hormone Receptor(TRβ1) |
| Passage | Endocrinology & Hormones |
| Background | It is a potent thyroid hormone that binds to and activates the β1 thyroid hormone receptor (TRβ1). |
| Biological Activity | Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ， respectively[1-3]. |
| Data Literature Source | [1]. Lin KH，et al. Stimulation of proliferation by 3，3'，5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [2]. Bhat MK，et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3，3'，5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. [3]. Hiroaki Shiohara，et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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