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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > (Z)-GuggulsteroneCAS：39025-23-5
Molecular Formula：C21H28O2
Molecular Weight：312.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 39025-23-5 |
| Name | (Z)-Guggulsterone |
| Molecular Formula | C21H28O2 |
| Molecular Weight | 312.45 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01310757 |
| SMILES | CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C |
| InChIKey | WDXRGPWQVHZTQJ-OSJVMJFVSA-N |
| InChI | InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13，2)17(15)8-10-21(16，18)3/h4，11，15，17-18H，5-10，12H2，1-3H3/b16-4+/t15-，17+，18+，20+，21-/m1/s1 |
| PubChem CID | 6450278 |
| Target Point | VEGFR;ACE2;SARS-CoV;FXR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK;Metabolic Enzyme&Protease;Anti-infection |
| Background | (Z) - Guggulsterone inhibits angiogenesis by inhibiting VEGF-VEGF-R2-Akt signal transduction axis. (Z) - Guggulsterone is also an FXR antagonist. (Z) - Guggulsterone can reduce the expression of ACE2 and SARS CoV-2 infection. |
| Biological Activity | (Z)-Guggulsterone， a constituent of Indian Ayurvedic medicinal plant Commiphora mukul， inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection[1-2]. |
| Data Literature Source | [1]. Xiao D，et al. z-Guggulsterone，a constituent of Ayurvedic medicinal plant Commiphora mukul，inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7(1):171-80. [2]. Brevini T，et al. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2. Nature. 2022 Dec 5. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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