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My CartCAS：774589-47-8
Molecular Formula：C20H20N2O4
Molecular Weight：352.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to light yellow Solid
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| CAS | 774589-47-8 |
| Name | ML406 |
| Molecular Formula | C20H20N2O4 |
| Molecular Weight | 352.38 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD06004413 |
| SMILES | CC(=O)C1=CC=C(C=C1)N2CCN(CC2)C(=O)C3=CC4=C(C=C3)OCO4 |
| InChIKey | DMJGPASMZSNEAZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H20N2O4/c1-14(23)15-2-5-17(6-3-15)21-8-10-22(11-9-21)20(24)16-4-7-18-19(12-16)26-13-25-18/h2-7，12H，8-11，13H2，1H3 |
| PubChem CID | 1245700 |
| Target Point | M.tuberculosis BioA |
| Passage | Anti-infection |
| Background | ML406 is a small molecule probe, which can exert anti tuberculosis activity by inhibiting M. tuberculosis BioA (DAPA synthase). |
| Biological Activity | ML406 is a small molecule probe that shows anti-tubercular activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis[1]. |
| IC50 | IC50 30 nM (BioA)[1] |
| Data Literature Source | [1]. Casalena D，et al. Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition. 2014 Apr 15 [updated 2015 Jan 16]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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