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My CartCAS：950225-08-8
Molecular Formula：C27H21FN4O
Molecular Weight：436.48
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
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| CAS | 950225-08-8 |
| Name | TTP-8307 |
| Molecular Formula | C27H21FN4O |
| Molecular Weight | 436.48 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC(C1=CC=C(C=C1)F)NC(=O)C2=CC=CC(=C2)C3=CN=C(N3)C4=CC5=CC=CC=C5C=N4 |
| InChIKey | SIBDJDZVNXVLEX-QGZVFWFLSA-N |
| InChI | InChI=1S/C27H21FN4O/c1-17(18-9-11-23(28)12-10-18)31-27(33)21-8-4-7-20(13-21)25-16-30-26(32-25)24-14-19-5-2-3-6-22(19)15-29-24/h2-17H，1H3，(H，30，32)(H，31，33)/t17-/m1/s1 |
| PubChem CID | 16739062 |
| Target Point | Antiviral |
| Passage | Anti-infection |
| Background | TTP-8307 is an effective inhibitor of replication of several nasal and enteroviruses (rhino-/enteroviruses). TTP-8307 exhibits antiviral activity through oxidation sterol-binding protein (OSBP). |
| Biological Activity | TTP-8307 是多种鼻病毒和肠病毒复制的抑制剂。TTP-8307 通过干扰病毒 RNA 的合成抑制 coxsackievirus B3 病毒 (CVB3; EC50=1.2 μM) 和 poliovirus 病毒。TTP-8307 通过氧化甾醇结合蛋白 (OSBP) 发挥抗病毒活性。[1-2] |
| Data Literature Source | [1]. De Palma AM，et al. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrob Agents Chemother. 2009 May;53(5):1850-7. [2]. Albulescu L，et al. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017 Apr;140:37-44. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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