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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > PirfenidoneCAS：53179-13-8
Molecular Formula：C12H11NO
Molecular Weight：185.22
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to light yellow Soild
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| CAS | 53179-13-8 |
| Name | Pirfenidone |
| Molecular Formula | C12H11NO |
| Molecular Weight | 185.22 |
| Solubility | Soluble in DMSO/Water ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to light yellow Soild |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00866047 |
| SMILES | CC1=CN(C(=O)C=C1)C2=CC=CC=C2 |
| InChIKey | ISWRGOKTTBVCFA-UHFFFAOYSA-N |
| InChI | InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H，1H3 |
| PubChem CID | 40632 |
| Target Point | CCL |
| Passage | Immunology & Inflammation |
| Background | It is an antifibrotic compound that can reduce the production of CCL2 and CCL12 in fibrocytes and has anti-inflammatory activity. |
| Biological Activity | Pirfenidone 是一种抗纤维化药物。Pirfenidone 具有生长抑制作用，可降低人胶质瘤细胞系中的 TGF-β2 蛋白水平。Pirfenidone 具有抗炎活性。[1-4] |
| Data Literature Source | [1]. Burghardt I，et al. Pirfenidone inhibits TGF-beta expression in malignant glioma cells. Biochem Biophys Res Commun. 2007 Mar 9;354(2):542-7. [2]. Nakazato H，et al. A novel anti-fibrotic agent pirfenidone suppresses tumor necrosis factor-alpha at the translational level. Eur J Pharmacol. 2002 Jun 20;446(1-3):177-85. [3]. Yang Y，et al. Inhibition of pirfenidone on TGF-beta2 induced proliferation，migration and epithlial-mesenchymal transition of human lens epithelial cells line SRA01/04. PLoS One. 2013;8(2):e56837. |
| Unit | Bottle |
| Specification | 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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