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R(+)-Methylindazone

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Cat.No：IM3480 Solarbio

CAS：54197-31-8

Molecular Formula：C₁₇H₁₈Cl₂O₄

Molecular Weight：357.23

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	54197-31-8
Name	R(+)-Methylindazone
Molecular Formula	C₁₇H₁₈Cl₂O₄
Molecular Weight	357.23
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD28133534
SMILES	CC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3CCCC3
InChIKey	RNOJGTHBMJBOSP-KRWDZBQOSA-N
InChI	InChI=1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6，10H，2-5，7-8H2，1H3，(H，20，21)/t17-/m0/s1
PubChem CID	656717
Target Point	Chloride Channel
Passage	Membrane Transporter&Ion Channel
Background	It is a powerful chloride channels blocker.
Biological Activity	R(+)-Methylindazone 是氯离子通道阻滞剂。R(+)-Methylindazone 能显著抑制 Nef-sdAb19 的相互作用，并能与 Nef 结合。[1-2]
Data Literature Source	[1]. Landry DW，et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244(4911):1469-72. [2]. Fan X，et al. A homogeneous time-resolved fluorescence-based high-throughput screening for discovery of inhibitors of Nef-sdAb19 interaction. Int J Oncol. 2015 Oct;47(4):1485-93.
Unit	Bottle
Specification	10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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