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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Skullcapflavone ⅡCAS：55084-08-7
Molecular Formula：C19H18O8
Molecular Weight：374.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 55084-08-7 |
| Name | Skullcapflavone Ⅱ |
| Molecular Formula | C19H18O8 |
| Molecular Weight | 374.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD02258879 |
| SMILES | COC1=CC=CC(=C1C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)OC)OC)O)O |
| InChIKey | GMQFOKBGMKVUQZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H18O8/c1-23-11-7-5-6-9(20)13(11)12-8-10(21)14-15(22)17(24-2)19(26-4)18(25-3)16(14)27-12/h5-8，20，22H，1-4H3 |
| PubChem CID | 124211 |
| Target Point | Osteoclast |
| Passage | Immunology & Inflammation |
| Background | Skullcapflavone II has been shown to regulate the differentiation, survival and function of osteoclasts. |
| Biological Activity | Skullcapflavone II 是一种从黄芩中提取的黄酮类化合物，具有抗炎和抗菌活性。Skullcapflavone II 能调节破骨细胞的分化、存活和功能。[1-2] |
| Data Literature Source | [1]. Solnier J，et al. Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species. Molecules. 2020 Feb 7;25(3):734. [2]. Lee J，et al. Skullcapflavone II inhibits osteoclastogenesis by regulating reactive oxygen species and attenuates the survival and resorption function of osteoclasts by modulating integrin signaling. FASEB J. 2019 Feb;33(2):2026-2036. [3]. Jang HY，et al. Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma. Int Immunopharmacol. 2012 Apr;12(4):666-74. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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