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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > LY-2334737CAS：892128-60-8
Molecular Formula：C17H25F2N3O5
Molecular Weight：389.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 892128-60-8 |
| Name | LY-2334737 |
| Molecular Formula | C17H25F2N3O5 |
| Molecular Weight | 389.39 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CCCC(CCC)C(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)O)(F)F |
| InChIKey | MEOYFIHNRBNEPI-UXIGCNINSA-N |
| InChI | InChI=1S/C17H25F2N3O5/c1-3-5-10(6-4-2)14(25)20-12-7-8-22(16(26)21-12)15-17(18，19)13(24)11(9-23)27-15/h7-8，10-11，13，15，23-24H，3-6，9H2，1-2H3，(H，20，21，25，26)/t11-，13-，15-/m1/s1 |
| PubChem CID | 11646777 |
| Target Point | Nucleoside Antimetabolite/Analog |
| Passage | DNA Damage&DNA Repai |
| Background | It is a nucleoside analogue with antiviral and anticancer activity. |
| Biological Activity | LY2334737 是一种核苷类似物，是吉西他滨的原药。LY2334737 具有抗病毒和抗癌作用，对肠道病毒 EV-A71 的感染具有抑制作用。[1-3] |
| Data Literature Source | [1]. Pratt SE，et al. Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells. Clin Cancer Res. 2013 Mar 1;19(5):1159-68. [2]. Sun J，et al. Drug repurposing of pyrimidine analogs as potent antiviral compounds against human enterovirus A71 infection with potential clinical applications. Sci Rep. 2020 May 18;10(1):8159. [3]. Francia G，et al. Low-dose metronomic oral dosing of a prodrug of gemcitabine (LY2334737) causes antitumor effects in the absence of inhibition of systemic vasculogenesis. Mol Cancer Ther. 2012 Mar;11(3):680-9. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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