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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > PD 169316CAS：152121-53-4
Molecular Formula：C20H13FN4O2
Molecular Weight：360.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 152121-53-4 |
| Name | PD 169316 |
| Molecular Formula | C20H13FN4O2 |
| Molecular Weight | 360.34 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12405019 |
| SMILES | C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)[N+](=O)[O-] |
| InChIKey | BGIYKDUASORTBB-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H，(H，23，24) |
| PubChem CID | 4712 |
| Target Point | p38 MAPK |
| Passage | MAPK |
| Background | PD 169316 is a highly effective and selective inhibitor of p38 MAP kinase. PD169316 selectively inhibits the kinase activity of phosphorylated p38, but does not impede the phosphorylation of p38 by upstream kinases. |
| Biological Activity | PD 169316 是一种 p38 MAP 激酶抑制剂，IC50 为 89 nM，可选择性地抑制磷酸化 p38 的激酶活性。PD169316 对Enterovirus71 具有抗病毒活性。[1-3] |
| IC50 | p38mAPK: 89nM(IC50)[3] |
| Data Literature Source | [1]. Fu Y，et al. The p38 MAPK inhibitor，PD169316，inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7. [2]. Kummer JL，et al. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem. 1997 Aug 15;272(33):20490-4. [3]. Zhang Z，et al. PD169316，a specific p38 inhibitor，shows antiviral activity against Enterovirus71. Virology. 2017 Aug;508:150-158. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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