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My CartCAS：107910-75-8
Molecular Formula：C9H12N5NaO4
Molecular Weight：277.21
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 107910-75-8 |
| Name | Ganciclovir Sodium |
| Molecular Formula | C9H12N5NaO4 |
| Molecular Weight | 277.21 |
| Solubility | Soluble in Water(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00873979 |
| SMILES | C1=NC2=C(N1COC(CO)CO)N=C(N=C2[O-])N.[Na+] |
| InChIKey | JJICLMJFIKGAAU-UHFFFAOYSA-M |
| InChI | InChI=1S/C9H13N5O4.Na/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;/h3，5，15-16H，1-2，4H2，(H3，10，12，13，17);/q;+1/p-1 |
| PubChem CID | 23700083 |
| Target Point | CMV |
| Passage | Anti-infection |
| Background | Ganciclovir (BW 759) sodium， a nucleoside analogue， is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2， CMV) and adenovirus serotypes 1， 2， 4， 6， 8， 10， 19， 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain[1-3]. |
| Biological Activity | Ganciclovir Sodium 是一种核苷类似物，是一种口服活性抗病毒药，对CMV 具有抗病毒活性。Ganciclovir Sodium 对疱疹病毒和其他一些 DNA 病毒也有活性，能抑制病毒体外复制。对猫疱疹病毒 1 型（FHV-1）的 IC50 值为 5.2 μM。[1-5] |
| IC50 | FHV-1: 5.2μM(IC50) [1] |
| Data Literature Source | [1]. Maggs DJ，et al. In vitro efficacy of ganciclovir，cidofovir，penciclovir，foscarnet，idoxuridine，and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403. [2]. Boujemla I，et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016 Aug;132:111-5. [3]. Fletcher CV，et al. Evaluation of ganciclovir for cytomegalovirus disease. DICP. 1989 Jan;23(1):5-12. [4]. Matthews T，et al. Antiviral activity and mechanism of action of ganciclovir. Rev Infect Dis. 1988 Jul-Aug;10 Suppl 3:S490-4. [5]. Duan J，et al. Dose and duration-dependence of ganciclovir treatment against murine cytomegalovirus infection in severe combined immunodeficient mice. Antiviral Res. 1998 Oct;39(3):189-97. |
| Unit | Bottle |
| Specification | 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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