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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Nintedanib Ethanesulfonate SaltCAS：656247-18-6
Molecular Formula：C33H39N5O7S
Molecular Weight：649.76
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 656247-18-6 |
| Name | Nintedanib Ethanesulfonate Salt |
| Molecular Formula | C33H39N5O7S |
| Molecular Weight | 649.76 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26142360 |
| Target Point | VEGFR1/2/3;FGFR1/2/3 ;PDGFR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | It is a potent triple inhibitor of VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β. |
| Biological Activity | Nintedanib Ethanesulfonate Salt 是一种强效的三重血管激酶抑制剂，对 VEGFR1/2/3、FGFR1/2/3 和 PDGFRα/β 的 IC50 分别为 34 nM/13 nM/13 nM、69 nM/37 nM/108 nM 和 59 nM/65 nM。[1] |
| IC50 | VEGFR1: 34nM(IC50);VEGFR2: 13nM(IC50);VEGFR3: 13nM(IC50);FGFR1: 69nM(IC50);FGFR2: 37nM(IC50);FGFR3: 108nM(IC50);PDGFRα: 9nM(IC50);PDGFRβ: 65nM(IC50) [1] |
| Data Literature Source | [1]. Hilberg F，et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008 Jun 15;68(12):4774-82. [2]. Suzuki N，et al. Effect of a novel oral chemotherapeutic agent containing a combination of trifluridine，tipiracil and the novel triple angiokinase inhibitor nintedanib，on human colorectal cancer xenografts. Oncol Rep. 2016 Dec;36(6):3123-3130. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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