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My CartCAS：1202764-53-1
Molecular Formula：C19H16ClN5OS
Molecular Weight：397.88
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1202764-53-1 |
| Name | B022 |
| Molecular Formula | C19H16ClN5OS |
| Molecular Weight | 397.88 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC(C#CC1=CC2=C(CCN2C3=NC(=NC=C3Cl)N)C=C1)(C4=NC=CS4)O |
| InChIKey | OKFYOOFXVBCIIP-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H16ClN5OS/c1-19(26，17-22-7-9-27-17)6-4-12-2-3-13-5-8-25(15(13)10-12)16-14(20)11-23-18(21)24-16/h2-3，7，9-11，26H，5，8H2，1H3，(H2，21，23，24) |
| PubChem CID | 58221879 |
| Target Point | NF-κB |
| Passage | NF-κB |
| Background | It is a potent and selective inhibitor of NF-κB induced kinase (NIK). |
| Biological Activity | B022 是一种强效的选择性 NF-κB 诱导激酶（NIK）抑制剂（Ki 为 4.2 nM；IC50=15.1 nM），B022 可保护肝脏免受毒素诱导的炎症、氧化应激和损伤。[1-2] |
| Data Literature Source | [1]. Ren X，et al. A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation，oxidative stress，and injury. FASEB J. 2017 Feb;31(2):711-718. [2]. Li X，et al. Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes. Mol Ther. 2020 Nov 4;28(11):2430-2441. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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