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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Cyclo(Phe-Pro)CAS：14705-60-3
Molecular Formula：C14H16N2O2
Molecular Weight：244.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 14705-60-3 |
| Name | Cyclo(Phe-Pro) |
| Molecular Formula | C14H16N2O2 |
| Molecular Weight | 244.29 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00101617 |
| SMILES | C1CC2C(=O)NC(C(=O)N2C1)CC3=CC=CC=C3 |
| InChIKey | QZBUWPVZSXDWSB-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H16N2O2/c17-13-12-7-4-8-16(12)14(18)11(15-13)9-10-5-2-1-3-6-10/h1-3，5-6，11-12H，4，7-9H2，(H，15，17) |
| PubChem CID | 99895 |
| Target Point | RIG-1;IRF3 |
| Passage | Immunology & Inflammation |
| Background | Cyclo(PH-Pro) is a quorum sensing molecule of Vibrio vulnificus that inhibits RIG-I polyubiquitination and inhibits IRF-3 activation and type I interferon production through specific interactions with RIG-I. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza viruses. |
| Biological Activity | Cyclo(Phe-Pro) 是一种弧菌群体感应分子，它通过与 RIG-I 的特异性相互作用抑制视黄酸诱导基因-I（RIG-I）的多泛素化，从而抑制 IRF-3 的激活和 IFN 的产生。Cyclo(Phe-Pro) 可增强对丙型肝炎病毒（HCV）以及仙台病毒和流感病毒的易感性。[1] |
| Data Literature Source | [1]. Lee W，et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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