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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > VU 0361737CAS：1161205-04-4
Molecular Formula：C13H11ClN2O2
Molecular Weight：262.69
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1161205-04-4 |
| Name | VU 0361737 |
| Molecular Formula | C13H11ClN2O2 |
| Molecular Weight | 262.69 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD00129668 |
| SMILES | COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl |
| InChIKey | ARYUXFNGXHNNDM-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H，1H3，(H，16，17) |
| PubChem CID | 44191096 |
| Target Point | mGluR |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | It is a selective positive allosteric regulator of mGlu4 receptor. |
| Biological Activity | VU0361737（ML-128）是一种强效、选择性的、中枢神经系统穿透性的 mGluR4 PAM 正变构调节剂，对人类和大鼠 mGluR4 受体的 EC50 分别为 240 nM 和 110 nM。VU0361737 具有神经保护作用，可能被用于帕金森病的研究。[1-2] |
| Data Literature Source | [1]. Jantas D，et al. Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation. Neurochem Int. 2015 Sep;88:124-37. [2]. Engers DW，et al. Discovery，synthesis，and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats. J Med Chem. 2011 Feb 24;54(4):1106-10. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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