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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > c-di-AMPCAS：54447-84-6
Molecular Formula：C20H24N10O12P2
Molecular Weight：658.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 54447-84-6 |
| Name | c-di-AMP |
| Molecular Formula | C20H24N10O12P2 |
| Molecular Weight | 658.41 |
| Solubility | Soluble in Water(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28167808 |
| SMILES | C1C2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O |
| InChIKey | PDXMFTWFFKBFIN-XPWFQUROSA-N |
| InChI | InChI=1S/C20H24N10O12P2/c21-15-9-17(25-3-23-15)29(5-27-9)19-11(31)13-7(39-19)1-37-43(33，34)42-14-8(2-38-44(35，36)41-13)40-20(12(14)32)30-6-28-10-16(22)24-4-26-18(10)30/h3-8，11-14，19-20，31-32H，1-2H2，(H，33，34)(H，35，36)(H2，21，23，25)(H2，22，24，26)/t7-，8-，11-，12-，13-，14-，19-，20-/m1/s1 |
| PubChem CID | 11158091 |
| Target Point | STING |
| Passage | Immunology & Inflammation |
| Background | c-di-AMP is a STING agonist, which binds to STING to activate TBK3-IRF3 signaling pathway and subsequently trigger the production of type I IFN and TNF. |
| Biological Activity | c-di-AMP 是一种 STING 激动剂，能与跨膜蛋白 STING 结合，从而激活 TBK3-IRF3 信号通路。c-di-AMP 也是细菌的第二信使，主要在革兰氏阳性细菌中调节细胞的生长、存活和毒力，同时也调节宿主的免疫反应。[1-3] |
| Data Literature Source | [1]. Fahmi T，et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulence of Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8):197. [2]. Ning H，et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous Adjuvant Induces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519. [3]. Hu H，et al. Glutamate Oxidase-Integrated Biomimetic Metal-Organic Framework Hybrids as Cascade Nanozymes for Ultrasensitive Glutamate Detection. J Agric Food Chem. 2022 Mar 30;70(12):3785-3794. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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