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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Cyclic-di-GMPCAS：61093-23-0
Molecular Formula：C20H24N10O14P2
Molecular Weight：690.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 61093-23-0 |
| Name | Cyclic-di-GMP |
| Molecular Formula | C20H24N10O14P2 |
| Molecular Weight | 690.41 |
| Solubility | Soluble in Water(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31563661 |
| SMILES | C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C6N=C(NC7=O)N)O)OP(=O)(O1)O)O |
| InChIKey | PKFDLKSEZWEFGL-MHARETSRSA-N |
| InChI | InChI=1S/C20H24N10O14P2/c21-19-25-13-7(15(33)27-19)23-3-29(13)17-9(31)11-5(41-17)1-39-45(35，36)44-12-6(2-40-46(37，38)43-11)42-18(10(12)32)30-4-24-8-14(30)26-20(22)28-16(8)34/h3-6，9-12，17-18，31-32H，1-2H2，(H，35，36)(H，37，38)(H3，21，25，27，33)(H3，22，26，28，34)/t5-，6-，9-，10-，11-，12-，17-，18-/m1/s1 |
| PubChem CID | 135440063 |
| Target Point | STING |
| Passage | Immunology & Inflammation |
| Background | It is a STING agonist. |
| Biological Activity | Cyclic-di-GMP 是一种 STING 激动剂和细菌第二信使，可协调细菌生物膜形成和细胞周期等方面。Cyclic-di-GMP 具有抗癌细胞增殖活性，能诱导 CD4 受体表达升高和细胞周期停滞，可用于癌症研究。[1-4] |
| Data Literature Source | [1]. Karaolis DK，et al. 3'，5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation. Biochem Biophys Res Commun. 2005 Apr 1;329(1):40-5. [2]. Steinberger O，et al. Elevated expression of the CD4 receptor and cell cycle arrest are induced in Jurkat cells by treatment with the novel cyclic dinucleotide 3'，5'-cyclic diguanylic acid. FEBS Lett. 1999 Feb 5;444(1):125-9. [3]. Wang Z，et al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015 Aug;64(8):1057-66. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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