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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Orphenadrine CitrateCAS：4682-36-4
Molecular Formula：C24H31NO8
Molecular Weight：461.5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 4682-36-4 |
| Name | Orphenadrine Citrate |
| Molecular Formula | C24H31NO8 |
| Molecular Weight | 461.5 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 225-137-5 |
| MDL | MFCD00079197 |
| SMILES | CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.C(C(=O)O)C(CC(=O)O)(C(=O)O)O |
| InChIKey | MMMNTDFSPSQXJP-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H23NO.C6H8O7/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;7-3(8)1-6(13，5(11)12)2-4(9)10/h4-12，18H，13-14H2，1-3H3;13H，1-2H2，(H，7，8)(H，9，10)(H，11，12) |
| PubChem CID | 83823 |
| Target Point | NMDAR |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | It is an effective non-competitive NMDA receptor antagonist with good neuroprotective effect, and can be used in the study of neurodegenerative diseases and related studies to relieve tremors caused by Parkinsons disease. |
| Biological Activity | Orphenadrine citrate 是一种口服有效的非竞争性 NMDA 受体拮抗剂 (可透过血脑屏障)，其 Ki 值为6.0 ± 0.7 μM。是一种肌肉松弛剂，作用于中枢神经系统。[1-2] |
| Data Literature Source | [1]. Pubill D，et al. Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo. Br J Pharmacol. 2001 Feb;132(3):693-702. [2]. Kornhuber J，et al. Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm Gen Sect. 1995;102(3):237-46. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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