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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > NimesulideCAS：51803-78-2
Molecular Formula：C13H12N2O5S
Molecular Weight：308.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 51803-78-2 |
| Name | Nimesulide |
| Molecular Formula | C13H12N2O5S |
| Molecular Weight | 308.31 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 257-431-4 |
| MDL | MFCD00079470 |
| SMILES | CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2 |
| InChIKey | HYWYRSMBCFDLJT-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H12N2O5S/c1-21(18，19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9，14H，1H3 |
| PubChem CID | 4495 |
| Target Point | COX-2 |
| Passage | Immunology & Inflammation |
| Background | Nimesulide is a selective COX-2 inhibitor with time-dependent inhibition. |
| Biological Activity | Nimesulide 是一种选择性 COX-2 抑制剂，其 IC50 值为 70 nM-70 μM，且具有时间依赖性，但对 COX-1 没有影响（IC50 值大于 100 μM）。Nimesulide 具有解热、抗炎、镇痛作用。[1-3] |
| IC50 | COX-2: 0.07-70μM(IC50)[1] |
| Data Literature Source | [1]. Vago T，et al. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung. 1995 Oct;45(10):1096-8. [2]. Werner MF，et al. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006 Aug 14;543(1-3):181-9. [3]. Gen S，et al. The effect of COX-2 inhibitor，nimesulide，on angiogenetic factors in primary endometrial carcinoma cell culture. Clin Exp Med. 2007 Mar;7(1):6-10. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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