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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Niflumic AcidCAS：4394-00-7
Molecular Formula：C13H9F3N2O2
Molecular Weight：282.22
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 4394-00-7 |
| Name | Niflumic Acid |
| Molecular Formula | C13H9F3N2O2 |
| Molecular Weight | 282.22 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 224-516-2 |
| MDL | MFCD00010569 |
| SMILES | C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F |
| InChIKey | JZFPYUNJRRFVQU-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H9F3N2O2/c14-13(15，16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H，(H，17，18)(H，19，20) |
| PubChem CID | 4488 |
| Target Point | Chloride Channel |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is a calcium - activated chloride channel blocker. |
| Biological Activity | Niflumic Acid 是一种钙激活氯通道阻滞剂和 COX-2 抑制剂，其 IC50 值为 100 nM，具有抗癌活性，被用于治疗关节和肌肉疼痛。[1-5] |
| IC50 | COX-1: 100nM(IC50)[2] |
| Data Literature Source | [1]. Criddle DN，et al. Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat. Br J Pharmacol. 1997 Mar;120(5):813-8. [2]. Kucherenko YV，et al. Niflumic acid affects store-operated Ca(2+)-permeable (SOC) and Ca (2+)-dependent K (+) and Cl (-) ion channels and induces apoptosis in K562 cells. J Membr Biol. 2014 Jul;247(7):627-38. [3]. Kim BM，et al. Combined treatment with the Cox-2 inhibitor niflumic acid and PPARγ ligand ciglitazone induces ER stress/caspase-8-mediated apoptosis in human lung cancer cells. Cancer Lett. 2011 Jan 28;300(2):134-44. [4]. Luo S，et al. Niflumic acid exhibits anti-tumor activity in nasopharyngeal carcinoma cells through affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Int J Clin Exp Pathol. 2015 Sep 1;8(9):9990-10001. [5]. Kondo M，et al. Niflumic acid inhibits goblet cell degranulation in a guinea pig asthma model. Allergol Int. 2012 Mar;61(1):133-42. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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