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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Methacholine ChlorideCAS：62-51-1
Molecular Formula：C8H18ClNO2
Molecular Weight：195.69
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 62-51-1 |
| Name | Methacholine Chloride |
| Molecular Formula | C8H18ClNO2 |
| Molecular Weight | 195.69 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-537-2 |
| MDL | MFCD00011817 |
| SMILES | CC(C[N+](C)(C)C)OC(=O)C.[Cl-] |
| InChIKey | JHPHVAVFUYTVCL-UHFFFAOYSA-M |
| InChI | InChI=1S/C8H18NO2.ClH/c1-7(11-8(2)10)6-9(3，4)5;/h7H，6H2，1-5H3;1H/q+1;/p-1 |
| PubChem CID | 6114 |
| Target Point | mAChR |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | It is a mAChR agonist for the selective muscarinic receptor. |
| Biological Activity | Methacholine Chloride 是一种有效的毒蕈碱-3 muscarinic-3 (M3) 激动剂，作用于平滑肌上的乙酰胆碱受体，导致支气管收缩和气道变窄。[1-4] |
| Data Literature Source | [1]. Kabara S，et al. Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs. Br J Anaesth. 2003 Sep;91(3):379-84. [2]. Folkerts G，et al. Bradykinin causes inhibition of methacholine-induced bronchoconstriction in vivo in mice. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jul;364(1):53-8. Gosens R，et al. Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells. Eur Respir J. 2009 Dec;34(6):1436-43. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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