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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > LornoxicamCAS：70374-39-9
Molecular Formula：C13H10ClN3O4S2
Molecular Weight：371.82
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 70374-39-9 |
| Name | Lornoxicam |
| Molecular Formula | C13H10ClN3O4S2 |
| Molecular Weight | 371.82 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00866163 |
| SMILES | CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3 |
| InChIKey | WLHQHAUOOXYABV-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17，20)21)6-8(14)22-12/h2-6，18H，1H3，(H，15，16，19) |
| PubChem CID | 54690031 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Lornoxicam is a highly active COX-1 and COX-2 inhibitor with analgesic， anti-inflammatory， antipyretic， and anticancer activities. |
| Biological Activity | Lornoxicam 是一种 COX-1 和 COX-2 抑制剂，是一种新型非甾体抗炎药。[1-3] |
| IC50 | COX-1: 5nM(IC50，in cells);COX-2: 45nM(IC50，in cells)[1] |
| Data Literature Source | [1]. Spyra S，et al. COX-2-selective inhibitors celecoxib and deracoxib modulate transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2017 Aug;174(16):2696-2705. [2]. Rose P，et al. Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). Clin Drug Investig. 2004;24(4):227-36. [3]. Bianchi M，et alE. Effects of lornoxicam，piroxicam，and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. Pharmacol Res. 2002 Feb;45(2):101-5. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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