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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > JNJ-7777120CAS：459168-41-3
Molecular Formula：C14H16ClN3O
Molecular Weight：277.75
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 459168-41-3 |
| Name | JNJ-7777120 |
| Molecular Formula | C14H16ClN3O |
| Molecular Weight | 277.75 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD04343337 |
| SMILES | CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)Cl |
| InChIKey | HUQJRYMLJBBEDO-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3，8-9，16H，4-7H2，1H3 |
| PubChem CID | 4908365 |
| Target Point | Histamine H4 Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | It is a selective histamine H4 receptor antagonist. |
| Biological Activity | JNJ-7777120 是一种选择性组胺 H4 受体拮抗剂，其Ki值为4.5 nM，具有抗瘙痒和抗炎活性。[1-2] |
| Data Literature Source | [1]. Thurmond RL，et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004 Apr;309(1):404-13. [2]. Ohsawa Y，et al. The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice. Allergy. 2012 Aug;67(8):1014-22. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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