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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > Carvedilol PhosphateCAS：610309-89-2
Molecular Formula：C24H26N2O4·H3PO4·1/2H2O
Molecular Weight：513.48
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 610309-89-2 |
| Name | Carvedilol Phosphate |
| Molecular Formula | C24H26N2O4·H3PO4·1/2H2O |
| Molecular Weight | 513.48 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.O.OP(=O)(O)O.OP(=O)(O)O |
| InChIKey | LHNYXTULDSJZRB-UHFFFAOYSA-N |
| InChI | InChI=1S/2C24H26N2O4.2H3O4P.H2O/c2*1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20;2*1-5(2，3)4;/h2*2-12，17，25-27H，13-16H2，1H3;2*(H3，1，2，3，4);1H2 |
| PubChem CID | 11954344 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is a non-selective beta /α-1 receptor blocker. It is also an inducer of autophagy and can inhibit NLRP3 inflammasome. |
| Biological Activity | Carvedilol Phosphate 是一种非选择性β/α-1 阻滞剂。可抑制脂质过氧化反应，IC50 为 5 μM。是一种多效降压药，可用于治疗心绞痛和充血性心力衰竭。是一种自噬诱导剂，可抑制 NLRP3 炎性体。[1-3] |
| IC50 | lipid peroxidation: 5μM(IC50)[1] |
| Data Literature Source | [1]. Eggertsen R，et al. Acute haemodynamic effects of carvedilol (BM 14190)，a new combined beta-adrenoceptor blocker and precapillary vasodilating agent，in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22. [2]. Feuerstein GZ，et al. Myocardial protection by the novel vasodilating beta-blocker，carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8. [3]. Wong WT，et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920. |
| Unit | Bottle |
| Specification | 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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