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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > ItanapracedCAS：749269-83-8
Molecular Formula：C16H11Cl2FO2
Molecular Weight：325.16
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 749269-83-8 |
| Name | Itanapraced |
| Molecular Formula | C16H11Cl2FO2 |
| Molecular Weight | 325.16 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18633206 |
| SMILES | C1CC1(C2=CC(=C(C=C2)C3=CC(=C(C=C3)Cl)Cl)F)C(=O)O |
| InChIKey | LIYLTQQDABRNRX-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H11Cl2FO2/c17-12-4-1-9(7-13(12)18)11-3-2-10(8-14(11)19)16(5-6-16)15(20)21/h1-4，7-8H，5-6H2，(H，20，21) |
| PubChem CID | 9996409 |
| Target Point | γ-secretase |
| Passage | Stem Cells;Neuronal Signaling |
| Background | It is A gamma-secretase regulator that reduces the secretion of Aβ42 and Aβ40. |
| Biological Activity | Itanapraced 是一种具有口服活性的 γ-secretase 调节剂和一种非甾体抗炎衍生物吗，可减少 Aβ42 和 Aβ40 的分泌，IC50 值分别为 3.6 和 18.4 μM，具有治疗阿尔茨海默病的疾病调节潜力。[1-2] |
| IC50 | Aβ40: 18.4μM(IC50);Aβ42: 3.6μM(IC50)[1] |
| Data Literature Source | [1]. Imbimbo BP，et al. 1-(3'，4'-Dichloro-2-fluoro[1，1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074)，a novel gamma-secretase modulator，reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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