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My CartCAS：30516-87-1
Molecular Formula：C10H13N5O4
Molecular Weight：267.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 30516-87-1 |
| Name | Zidovudine |
| Molecular Formula | C10H13N5O4 |
| Molecular Weight | 267.24 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 623-849-4 |
| MDL | MFCD00006536 |
| SMILES | CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-] |
| InChIKey | HBOMLICNUCNMMY-XLPZGREQSA-N |
| InChI | InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3，6-8，16H，2，4H2，1H3，(H，12，17，18)/t6-，7+，8+/m0/s1 |
| PubChem CID | 35370 |
| Target Point | Reverse Transcriptase |
| Passage | Anti-infection |
| Background | It is a nucleoside reverse transcriptase inhibitor (NRTI). |
| Biological Activity | Zidovudine 是一种逆转录酶抑制剂，能够降低同源重组效率，可能用于 HIV 感染的研究。[1] |
| Data Literature Source | [1]. Gray LR，et al. The NRTIs lamivudine，stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes. PLoS One. 2013 Apr 16;8(4):e62196. [2]. Chiang G，et al. Inhibition of HIV-1 replication by hydroxychloroquine: mechanism of action and comparison with zidovudine. Clin Ther. 1996 Nov-Dec;18(6):1080-92. [3]. Mizutani T，et al. Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7122-9. [4]. Chitnis S，et al. Zidovudine (AZT) treatment suppresses granulocyte-monocyte colony stimulating factor receptor type alpha (GM-CSFR alpha) gene expression in murine bone marrow cells. Life Sci. 2002 Jul 12;71(8):967-78. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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