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My CartCAS：173903-47-4
Molecular Formula：C10H7N3O4S
Molecular Weight：265.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 173903-47-4 |
| Name | Tizoxanide |
| Molecular Formula | C10H7N3O4S |
| Molecular Weight | 265.25 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD07484970 |
| SMILES | C1=CC=C(C(=C1)C(=O)NC2=NC=C(S2)[N+](=O)[O-])O |
| InChIKey | FDTZUTSGGSRHQF-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5，14H，(H，11，12，15) |
| PubChem CID | 394397 |
| Target Point | Bacterial;Parasite;HIV;HBV;HCV |
| Passage | Anti-infection |
| Background | It is a thiazolamine antibiotic, with anti-anaerobic bacteria, antigenic animals and antiviral activities. |
| Biological Activity | Tizoxanide 是 Nitazoxanide 的主要活性代谢产物，具有抗 HIV-1 活性，对 HBV 和 HCV 的复制具有强效抑制作用，其 EC50 值分别为 0.46μM 和 0.15μM。抑制促炎细胞因子的产生，抑制 LPS 处理的巨噬细胞中 NF-κB 和 MAPK 信号通路的激活。[1-4] |
| Data Literature Source | [1]. Li F，et al. Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice. Acta Pharm Sin B. 2022 Mar;12(3):1322-1338. [2]. Korba BE，et al. Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide. Antimicrob Agents Chemother. 2008 Nov;52(11):4069-71. [3]. Korba BE，et al. Nitazoxanide，tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 2008 Jan;77(1):56-63. [4]. Shou J，et al. Tizoxanide Inhibits Inflammation in LPS-Activated RAW264.7 Macrophages via the Suppression of NF-κB and MAPK Activation. Inflammation. 2019 Aug;42(4):1336-1349. [5]. Guo S，et al. Analysis of tizoxanide，active metabolite of nitazoxanide，in rat brain tissue and plasma by UHPLC-MS/MS. Biomed Chromatogr. 2020 Feb;34(2):e4716. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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