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My CartCAS：500287-72-9
Molecular Formula：C22H18N6
Molecular Weight：366.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 500287-72-9 |
| Name | Rilpivirine |
| Molecular Formula | C22H18N6 |
| Molecular Weight | 366.42 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11046372 |
| SMILES | CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)C=CC#N |
| InChIKey | YIBOMRUWOWDFLG-ONEGZZNKSA-N |
| InChI | InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9，11-13H，1-2H3，(H2，25，26，27，28)/b4-3+ |
| PubChem CID | 6451164 |
| Target Point | Reverse Transcriptase;HIV |
| Passage | Anti-infection |
| Background | It is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI) with high anti-HIV activity. |
| Biological Activity | Rilpivirine 是一种有效和特异性的二芳基嘧啶 (DAPY) 非核苷逆转录酶抑制剂 (NNRTI)，对野生型 HIV (EC50=0.4 nM) 和突变体 (EC50=0.1-2.0 nM) 具有很高的抗病毒活性，被用于治疗HIV-1感染。[1-2] |
| Data Literature Source | [1]. Janssen PA，et al. In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2，6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474，rilpivirine). J Med Chem. 2005 Mar 24;48(6):1901-9. [2].Azijn H，et al. TMC278，a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI)，active against wild-type and NNRTI-resistant HIV-1. Antimicrob Agents Chemother. 2010 Feb;54(2):718-27. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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