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My CartCAS：518048-05-0
Molecular Formula：C20H21FN6O5
Molecular Weight：444.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 518048-05-0 |
| Name | Raltegravir |
| Molecular Formula | C20H21FN6O5 |
| Molecular Weight | 444.42 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD10698872 |
| SMILES | CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F |
| InChIKey | CZFFBEXEKNGXKS-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H21FN6O5/c1-10-25-26-17(32-10)16(30)24-20(2，3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11/h5-8，28H，9H2，1-4H3，(H，22，29)(H，24，30) |
| PubChem CID | 54671008 |
| Target Point | HIV Integrase |
| Passage | Anti-infection |
| Background | It is a potent HIV integrase inhibitor. |
| Biological Activity | Raltegravir 是一种有效的integrase (IN)抑制剂，作用于WT和S217Q PFV IN，在无细胞试验中IC50分别为90 nM和40 nM。它对HIV-1 IN的选择性比对其他相关Mg2+依赖性酶要高1000倍以上，如HCV聚合酶、HIV反转录酶、HIV RNaseH、人类α-，β-，γ-聚合酶。[1] |
| IC50 | Integrase(S217Q PFV): 40nM(IC50);Integrase(WT PFV) : 90nM(IC50) [1] |
| Data Literature Source | [1]. Hare S，et al. Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):20057-62. [2]. Hicks C，et al. Raltegravir: the first HIV type 1 integrase inhibitor. Clin Infect Dis. 2009 Apr 1;48(7):931-9. [3]. Moss DM，et al. Divalent metals and pH alter raltegravir disposition in vitro. Antimicrob Agents Chemother. 2012 Jun;56(6):3020-6. [4].Hare S，et al. Structural and functional analyses of the second-generation integrase strand transfer inhibitor dolutegravir (S/GSK1349572). Mol Pharmacol. 2011 Oct;80(4):565-72. [5]. Lewis MG，et al. Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy. Retrovirology. 2010 Mar 16;7:21. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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