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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Pitolisant HydrochlorideCAS：903576-44-3
Molecular Formula：C17H27Cl2NO
Molecular Weight：332.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 903576-44-3 |
| Name | Pitolisant Hydrochloride |
| Molecular Formula | C17H27Cl2NO |
| Molecular Weight | 332.31 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09970745 |
| SMILES | C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl.Cl |
| InChIKey | XLFKECRRMPOAQS-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H26ClNO.ClH/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19;/h7-10H，1-6，11-15H2;1H |
| PubChem CID | 11551689 |
| Target Point | Histamine H3 Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | It is an effective selective reverse agonist for the H3 receptor. |
| Biological Activity | Pitolisant Hydrochloride 是一种对重组人组胺 H3 受体具有强效和选择性的非咪唑类反向激动剂（Ki=0.16 nM，EC50=1.5 nM）。[1] |
| Data Literature Source | [1]. Ligneau X，et al. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine，hydrochloride]，a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320(1):365-75. [2]. Dudek M，et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice. Metab Brain Dis. 2016 Oct;31(5):1023-9. [3]. Uguen M，et al. Preclinical evaluation of the abuse potential of Pitolisant，a histamine H receptor inverse agonist/antagonist compared with Modafinil. Br J Pharmacol. 2013 Jun;169(3):632-44. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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