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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > O-DesvenlafaxineCAS：93413-62-8
Molecular Formula：C16H25NO2
Molecular Weight：263.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 93413-62-8 |
| Name | O-Desvenlafaxine |
| Molecular Formula | C16H25NO2 |
| Molecular Weight | 263.38 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00871934 |
| SMILES | CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O |
| InChIKey | KYYIDSXMWOZKMP-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9，15，18-19H，3-5，10-12H2，1-2H3 |
| PubChem CID | 125017 |
| Target Point | Serotonin Transporter;Adrenergic Receptor |
| Passage | Neuronal Signaling;Endocrinology & Hormones;GPCR & G Protein |
| Background | It is a serotonin (5-HT) and norepinephrine (NE) reabsorption inhibitor. |
| Biological Activity | O-Desvenlafaxine 是一种具有口服活性和 BBB 穿透性的 5-HT 和去甲肾上腺素再摄取抑制剂，对 hSERT 和 hNET 的 IC50 值分别为 47.3 nM 和 531.3 nM。是文拉法辛（Venlafaxine）分离出的主要活性代谢产物（HY-B0196）的琥珀酸盐形式，是地文拉法辛与人类多巴胺（DA）转运体的结合亲和力较弱（100 μM时抑制率为62%）。[1-2] |
| IC50 | hSERT: 47.3nM(IC50);hNET: 531.3nM(IC50)[1] |
| Data Literature Source | [1]. Deecher DC，et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther. 2006 Aug;318(2):657-65. [2]. opko MA Jr，et al. Desvenlafaxine: another 'me too' drug Ann Pharmacother. 2008 Oct;42(10):1439-46. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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