{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > NizatidineCAS：76963-41-2
Molecular Formula：C12H21N5O2S2
Molecular Weight：331.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 76963-41-2 |
| Name | Nizatidine |
| Molecular Formula | C12H21N5O2S2 |
| Molecular Weight | 331.46 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00865660 |
| SMILES | CNC(=C[N+](=O)[O-])NCCSCC1=CSC(=N1)CN(C)C |
| InChIKey | SGXXNSQHWDMGGP-IZZDOVSWSA-N |
| InChI | InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6，9，13-14H，4-5，7-8H2，1-3H3/b11-6+ |
| PubChem CID | 3033637 |
| Target Point | Histamine H2 Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | It is a histamine H2 receptor antagonist and can be used in the study of gastric ulcer. |
| Biological Activity | Nizatidine 是一种选择性组胺 H2 受体拮抗剂，作用于AChE，IC50为6.7 nM，是一种有效的胃酸分泌抑制剂。[1-4] |
| IC50 | Histamine H2 receptor: 0.9nM(IC50)[1];AChE: 6.7μM[4] |
| Data Literature Source | [1]. Lin TM，et al. Actions of nizatidine，a selective histamine H2-receptor antagonist，on gastric acid secretion in dogs，rats and frogs. J Pharmacol Exp Ther. 1986 Nov;239(2):406-10. [2]. Li S ，et al.Abstract 4004: The H2 receptor antagonist nizatidine inhibits carcinogenesis in two rodent models of hepatocellular carcinoma[J].Cancer Research，2018，78(13 Supplement):4004-4004.DOI:10.1158/1538-7445.AM2018-4004. [3]. Alazzouni A S ，et al.Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones[J].The Journal of Basic and Applied Zoology，2020，81(1).DOI:10.1186/s41936-020-00196-6. [4]. Ueki S，et al. Gastroprokinetic activity of nizatidine，a new H2-receptor antagonist，and its possible mechanism of action in dogs and rats. J Pharmacol Exp Ther. 1993 Jan;264(1):152-7. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
