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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > LevodropropizineCAS：99291-25-5
Molecular Formula：C13H20N2O2
Molecular Weight：236.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 99291-25-5 |
| Name | Levodropropizine |
| Molecular Formula | C13H20N2O2 |
| Molecular Weight | 236.31 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00866852 |
| SMILES | C1CN(CCN1CC(CO)O)C2=CC=CC=C2 |
| InChIKey | PTVWPYVOOKLBCG-ZDUSSCGKSA-N |
| InChI | InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5，13，16-17H，6-11H2/t13-/m0/s1 |
| PubChem CID | 65859 |
| Target Point | Histamine Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | Levodropropizine inhibits histamine receptors and reduces cough by interfering with stimulatory activation of peripheral sensory nerve endings and modulating neuropeptides involved in the cough reflex. |
| Biological Activity | Levodropropizine 可以抗过敏并抑制组胺受体，通过干扰外围感觉神经末端的刺激活化作用以及调节参与咳嗽反射的神经肽来减轻咳嗽。[1-5] |
| Data Literature Source | [1]. Melillo G，et al. General pharmacology of the new antitussive levodropropizine. Arzneimittelforschung. 1988 Aug;38(8):1144-50. [2]. Shams H，et al. Effects of levodropropizine on vagal afferent C-fibres in the cat. Br J Pharmacol. 1996 Mar;117(5):853-8. [3]. Malandrino S，et al. Antitussive properties of levodropropizine. Arzneimittelforschung. 1988 Aug;38(8):1141-3. [4]. Lavezzo A，et al. Peripheral site of action of levodropropizine in experimentally-induced cough: role of sensory neuropeptides. Pulm Pharmacol. 1992 Jun;5(2):143-7. [5]. Yamawaki I，et al. Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea. Eur J Pharmacol. 1993 Oct 12;243(1):1-6. |
| Unit | Bottle |
| Specification | 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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