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My CartCAS：154598-52-4
Molecular Formula：C14H9ClF3NO2
Molecular Weight：315.68
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 154598-52-4 |
| Name | Efavirenz |
| Molecular Formula | C14H9ClF3NO2 |
| Molecular Weight | 315.68 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD05662344 |
| SMILES | C1CC1C#CC2(C3=C(C=CC(=C3)Cl)NC(=O)O2)C(F)(F)F |
| InChIKey | XPOQHMRABVBWPR-ZDUSSCGKSA-N |
| InChI | InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16，17)18，21-12(20)19-11)6-5-8-1- 2-8/h3-4，7-8H，1-2H2，(H，19，20)/t13-/m0/s1 |
| PubChem CID | 64139 |
| Target Point | Reverse Transcriptase |
| Passage | Anti-infection |
| Background | It is a non - nucleoside reverse transcriptase inhibitor with antiviral activity. |
| Biological Activity | Efavirenz 是一种合成的 HIV-1 逆转录酶的强效抑制剂，其 Ki 值为 2.93 nM，在细胞培养中抑制 HIV-1 复制扩散的 IC95 值为 1.5 nM。[1] |
| Data Literature Source | [1]. Young SD，et al，Carroll SS，et al. L-743，726 (DMP-266): a novel，highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5. [2]. Funes HA，et al. Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines. J Antimicrob Chemother. 2015 Aug;70(8):2249-54. [3]. Apostolova N，et al. ER stress in human hepatic cells treated with Efavirenz: mitochondria again. J Hepatol. 2013 Oct;59(4):780-9. [4]. Caulk AW，et al. Efavirenz treatment causes arterial stiffening in apolipoprotein E-null mice. J Biomech. 2015 Jul 16;48(10):2176-80. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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