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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > CTEPCAS：871362-31-1
Molecular Formula：C19H13ClF3N3O
Molecular Weight：391.77
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 871362-31-1 |
| Name | CTEP |
| Molecular Formula | C19H13ClF3N3O |
| Molecular Weight | 391.77 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22665726 |
| SMILES | CC1=C(N=C(N1C2=CC=C(C=C2)OC(F)(F)F)C)C#CC3=CC(=NC=C3)Cl |
| InChIKey | GOHCTCOGYKAJLZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H13ClF3N3O/c1-12-17(8-3-14-9-10-24-18(20)11-14)25-13(2)26(12)15-4-6-16(7-5-15)27-19(21，22)23/h4-7，9-11H，1-2H3 |
| PubChem CID | 11646823 |
| Target Point | mGluR |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | It is a long-acting mGlu5 receptor alloantagonist. |
| Biological Activity | CTEP 是一种新型、长效、口服生物可利用的 mGlu5 受体异构拮抗剂，其 IC50 值为 2.2 nM，与其他 mGlu 受体相比，具有 > 1000 倍的选择性。[1-2] |
| IC50 | mGlu5 Receptor: 2.2nM(IC50)[1] |
| Data Literature Source | [1]. Lindemann L，et al. CTEP: a novel，potent，long-acting，and orally bioavailable metabotropic glutamate receptor 5 inhibitor. J Pharmacol Exp Ther. 2011 Nov;339(2): 474-86. [2]. Michalon A，et al. Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice. Neuron. 2012 Apr 12;74(1): 49-56. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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